HFE gene mutations and iron status of Brazilian blood donors

Mutations of the HFE and TFR2 genes have been associated with iron overload. HFE and TFR2 mutations were assessed in blood donors, and the relationship with iron status was evaluated. Subjects (N = 542) were recruited at the Hemocentro da Santa Casa de São Paulo, São Paulo, Brazil. Iron status was not influenced by HFE mutations in women and was independent of blood donation frequency. In contrast, men carrying the HFE 282CY genotype had lower total iron-binding capacity (TIBC) than HFE 282CC genotype carriers. Men who donated blood for the first time and were carriers of the HFE 282CY genotype had higher transferrin saturation values and lower TIBC concentrations than those with the homozygous wild genotype for the HFE C282Y mutation. Moreover, in this group of blood donors, carriers of HFE 63DD plus 63HD genotypes had higher serum ferritin values than those with the homozygous wild genotype for HFE H63D mutation. Multiple linear regression analysis showed that HFE 282CY leads to a 17.21 percent increase (P = 0.018) and a 83.65 percent decrease (P = 0.007) in transferrin saturation and TIBC, respectively. In addition, serum ferritin is influenced by age (3.91 percent, P = 0.001) and the HFE 63HD plus DD genotype (55.84 percent, P = 0.021). In conclusion, the HFE 282Y and 65C alleles were rare, while the HFE 63D allele was frequent in Brazilian blood donors. The HFE C282Y and H63D mutations were associated with alterations in iron status in blood donors in a gender-dependent manner.

Variaçäo sazonal de macro e microelementos da Brachiaria decumbens sob pastejo contínuo em solos arenoso e argiloso / Seasonal changes of macro and microelements of Brachiaria decumbens on continuous grazing in sandy and clayey soils

Avaliaram-se mudanças sazonais dos minerais de cinco tipos de amostragens de B. decumbens sob pastejo contínuo (folhas, colmos, parte aérea, resíduo seco e simulaçäo do pastejo animal - SPA), oriundos de dois tipos de solos (arenoso e argiloso). Utilizou-se um esquema de parcela subdividida no qual os subtratamentos compreendiam 10 épocas de amostragens e o tipo de solo dois tratamentos. Os macro e microelementos estudados foram: Ca, P, K e Mg e Cu, Fe, Zn e Mn, respectivamente. A composiçäo dos minerais foi alterada em funçäo do tipo de amostragem. Amostras de folhas apresentaram maiores teores de Ca, P, K, Mg e Cu do que amostras de colmos. Amostras SPA tiveram valores ligeiramente inferiores aos das folha. O Ca foi o elemento menos translocável nas amostragens, P foi o mais móvel, seguido pelo K, com menor intensidade. A maior presença de resíduo seco nas amostragens colhidas na época das secas proporcionou teores reduzidos de P, K, Mg, Cu e Fe. O solo argiloso produziu forragens com teores elevados de K, Cu, Fe, Zn e Mn e o arenoso com Mg, em todos os tipos de amostragens

Patrón de masticación en las clases III de angle / Masticatory pattern in Angle class III patients

Se seleccionó una muestra de 12 pacientes (cuatro hombres y ocho mujeres) con edad promedio de 17.6 años, los cuales tenían diagnóstico de clase III de Angle y mordida cruzada posterior.- Los resultados mostraron que el 75 por ciento de los pacientes desplazaban la mandíbula hacia el lado de trabajo. El 66 por ciento de la muestra en masticación izquierda y el 75 por ciento en masticación derecha tenían desplazamiento condilar hacia el lado de no trabajo. No se encontró relación entre el desplazamiento del cóndilo con la situación de la mordida cruzada ni con la severidad de la misma...